Kep LS Syrup

MECHANISM OF ACTION:
Levosalbutamol is a selective β-2-adrenoceptor agonist. At therapeutic doses it acts on the β-2-adrenoreceptors of bronchial muscle with little or no action on the α1-adrenoreceptors of cardiac muscle. Levosalbutamol (LEV) has approximately 2 fold greater affinity than racemic salbutamol (RAC) for the β2 adrenergic receptor and approximately 100 fold greater binding affinity than S-Salbutamol. Levosalbutamol stimulates the production of intracellular cyclic-AMP, enhancing the binding of intracellular calcium to the cell membrane and endoplasmic reticulum, resulting in bronchodilation. It also enhances mucociliary clearance.

Ambroxol:
Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It stimulates synthesis and release of surfactant by type IIpneumocytes. Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.

Guaiphenesin:
Guaiphenesin is an expectorant. It increases the output of sputum and bronchial secretions by reducing adhesiveness and surface tension. By increasing the volume of bronchial secretions, it reduces the viscosity of tenacious sputum. The increased flow of less viscid secretions also promotes ciliary action.

INDICATIONS:
KEP-LS Syrup is indicated for the treatment of productive cough associated with bronchospasm in conditions such as bronchitis and bronchial asthma as well as all conditions associated with tenacious mucus, wheezing and chest congestion.