ECOTHRAL 250
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ECOTHRAL 250

August 1, 2015
  • ECOTHRAL is a brand of Azithromycin. Azithromycin is an azalide, a subclass of macrolide antibiotics. Active against Gram-positive, Gram negative as well as atypical bacteria

Azithromycin Mechanism of Action

  • Inhibits protein synthesis by reversibly binding to the 50S ribosomal subunit

 

INDICATIONS AND CLINICAL USE

  • Community-acquired pneumonia
  • Acute exacerbation of chronic bronchitis
  • Pharyngitis, Tonsillitis, Acute bacterial sinusitis
  • Chlamydial infections
  • Skin & Soft Tissue Infections
  • Pelvic inflammatory disease

 

Dosage and administration: Oral 500mg OD x 3 days OR 500 mg as a single dose on Day 1, followed by 250 mg once daily on Days 2 through 5. In Children: 10mg/kg/day for 3 days.

 

Special populations

Pregnant Women: Pregnancy Category B. The safety and efficacy of Ecothral in pregnancy have not been established.

Nursing Mothers

It is not known whether Azithromycin is excreted in human milk. Caution should be exercised when Azithromycin is administered to a nursing woman.

Pediatric use:

Safety and effectiveness in the treatment of paediatric patients under 6 months of age have not been established.

Geriatric Use:

Dosage adjustment does not appear to be necessary for older patients with normal renal function (for their age) and hepatic function
Adverse reactions: Headache, body ache, nausea, vomiting, diarrhea, or abdominal pain. Rarely but potentially serious side effects were angioedema and cholestatic jaundice.

Contra-indications: Azithromycinis contraindicated in patients with known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic

Precautions: Caution should be exercised when prescribing Azithromycin in patients with impaired hepatic function and impaired renal function.