TWAGIC SPAS
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TWAGIC SPAS

September 8, 2016

Each film coated tablet contains:

Mefenamic Acid IP 500mg
Pamabrom USP 25mg
Dicyclomine Hydrochloride IP 10mg

DESCRIPTION:
TWAGIC SPAS is a combination of Mefenamic Acid which is a non-steroidal anti-inflammatory drug, Dicyclomine Hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent and Pamabrom which helps to relieve water retention symptoms of pre-menstrual and menstrual periods.

MECHANISM OF ACTION:
Mefenamic Acid inhibits the enzymes cyclooxygenase COX-1 and COX-2 and reduces the formation of prostaglandins and leukotrienes. It also acts as an antagonist at prostaglandin receptor sites. It has analgesic and antipyretic properties with minor anti-inflammatory activity.

Dicyclomine relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells.

Pamabrom: Pamabrom which acts a diuretic. It acts by increasing renal blood flow and glomerular filtration rate, thus promoting dieresis.

INDICATIONS:
Spasmodic dysmenorrhea, symptomatic relief of colics such as intestinal, biliary and ureteric.

CONTRAINDICATIONS:
Contraindicated in patients with known hypersensitivity to this product or any of its ingredients or another NSAID.

SIDE EFFECTS:
Dry mouth, dizziness, nausea, headache, skin rash.

DRUG INTERACTIONS:
Dicyclomine can interact with drugs having anti-cholinergic activity and prokinetics.

DOSAGE:
As directed by the physician.