Kepler Onyx & Kepler OpalItler 200 Capsule
ITLER 200 Capsule
Itraconazole with betacyclodextrin 200 mg Capsule
Itraconazole
Itraconazole is an triazole medicine used to treat fungal infections.
Itraconazole is effective against a broad spectrum of fungi including:
- Dermatophytes (tinea infections)
- Yeasts such as candida and malassezia infections
- Systemic fungal infections such as histoplasma, aspergillus, coccidiodomycosis, chromoblastomycosis.
Itraconazole is sometimes used for inflammatory skin diseases such as atopic eczema, seborrhoeic dermatitis or psoriasis, if a fungus or yeast is thought to be contributing to the condition.
Itraconazole binds to the fungal p450 enzymes and stops the cells making ergosterol, the main component of the cell wall.
Dosage
| Infection | Dose |
|---|---|
| Onychomycosis (fingernail) | 200 mg BD for 1 week; two courses 1 month apart |
| Onychomycosis (toenail) | 200 mg OD for 12 weeks |
| Tinea corporis, tinea cruris | 200 mg OD for one week OR 100mg OD for 2 weeks |
| Tinea pedis, tinea manuum | 200 mg BD for one week OR 100mg OD for 2-4 weeks |
| Tinea unguium | 200 mg OD for 6-8 weeks (fingernails) or 3-4 months (toenails) |
| Vulvovaginal candidiasis | 200 mg BD for a day OR 200 mg OD for 3 days |
| Pityriasis versicolor | 200 mg OD for 10 days, with a preventative dose of 200mg once monthly for 6 months |
| Oral candidiasis | 100 mg OD for two weeks |
| Aspergillosis | 200 mg BD for 2 days followed by 200 mg IV daily for 2 wks then 400 mg PO daily |
| Blastomycosis | 200 mg TID a day for 3 days, then 200 mg orally once or twice a day Duration of therapy: 6 to 12 months |
| Histoplasmosis | 200 mg TID a day for the first 3 days than 200 mg OD or BD day |
